Aluminum affects glial system and behavior of rats |
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Authors: | Hasna Erazi Wafa SansarSamir Ahboucha Halima Gamrani |
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Institution: | Neurosciences, Pharmacology and Environment Research Team Laboratory, University Cadi Ayyad, Faculty of Sciences Semlalia, avenue My-Abdellah, BP 2930, 4000 Marrakech, Morocco |
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Abstract: | Aluminum (Al) has been associated with neuronal dysfunction. These neuronal changes may involve glial alterations. We intend to evaluate the consequence of Al on the glial system and the behavior of rats exposed chronically to 0.3% of aluminum chloride in drinking water during 4 months in adulthood (A) or since intra-uterine age (IU); animals from this latter group were sacrificed at four months of age. Our data show an intense glial fibrillary acidic protein (GFAP)-immunoreactivity with a high density of astrocytes in both treated groups compared with controls. However, in IU rats, astrocytes display prominent glial cell bodies and processes. A and IU rat groups perform a significantly reduced locomotor activity. However, using the dark/light box test, the IU rats prefer to spend more time in the enlightened compartment compared to other groups. Behavioral and glial changes caused by Al exposure bring support for the role of Al in brain dysfunction involving glial alterations. |
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Keywords: | Rat brain Chronic poisoning Aluminum Behavior Anxiety Immunohistochemistry GFAP |
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