| 蝮蛇抗栓酶对动脉粥样硬化影响的实验研究 |
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| 引用本文： | 周启棣 王克腾. 蝮蛇抗栓酶对动脉粥样硬化影响的实验研究[J]. 蛇志, 1995, 7(2): 14-17 |
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| 作者姓名： | 周启棣 王克腾 |
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| 作者单位： | 湖北省十堰市东风汽车公司中心医院 |
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| 摘 要： | 通过用蝮蛇栓酶对家兔实验性动脉粥样硬化影响的观察，发现Ｓｖａｔｅ能明显抑制家兔主动脉ＡＳ，同时能明显降低血液丙二醛、血栓素及甘油三酯含量，能升高血液超氧化物歧２化酶活性及前列环素含量。说明Ｓｖａｔｅ能预防ＡＳ，其机制与Ｓｖａｔｅ减轻自由基损伤、恢复前列环素血检 平衡及降血脂密切相关。
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| 关 键 词： | 蝮蛇抗栓酶 动脉粥样硬化 药理学 |
Experimental Research of Svate the Atherosclerosis |
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| Zhou Qidi, Wang Keteng. Experimental Research of Svate the Atherosclerosis[J]. Journal of Snake, 1995, 7(2): 14-17 |
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| Authors: | Zhou Qidi Wang Keteng |
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| Abstract: | Our experimental observations of the effcet of snake Venom antithrombotic Enzyme(Svate)on rabbit atherosclerosis(AS),show that svate can inhiht AS of the rabbit aorta effectively. It can also significantly reduce the blood level of malondialdehyde(MDA),thromboxane(TXA_2)and Triglyceride(TG),enhance the activity of superoxide dismutase(SD) and increase the blood confert of prostacyclin(PGI_2).Our results indicate that svate can prevent AS,and the mechanism is related to the fact that svate can minimige the injury produced by oxygen free radical.maintain the balance of PGI_2/TXA_3 , and lower the level of Triglyceride (TG). |
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| Keywords: | Svate AS Rabbit |
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