Assignment of casein kinase 2 alpha sequences to two different human chromosomes |
| |
| Authors: | Brigitte Boldyreff Christine Klett Elisabeth Göttert Ad Geurts van Kessel Horst Hameister Olaf-Georg Issinger |
| |
| Institution: | (1) Institut für Humangenetik, Universität des Saarlandes, W-6650, 3 Homburg, Federal Republic of Germany;(2) Abteilung für Klinische Genetik der Universität, Postfach 4066, W-7900 Ulm, Federal Republic of Germany;(3) Department of Human Genetics, University Hospital Nijmegen, P.O.Box 9101, NL-6500 HB Nijmegen, The Netherlands |
| |
| Abstract: | Summary Human casein kinase 2 alpha gene (CK-2-alpha) sequences have been localized within the human genome by in situ hybridization and somatic cell hybrid analysis using a CK-2 alpha cDNA as a probe. By in situ hybridization, the CK-2 alpha cDNA could be assigned to two different loci, one on 11p15.1-ter and one on 20p13. The existence of two separate chromosomal loci suggests that CK-2 alpha is a member of a gene family. Only the locus on chromosome 11 was confirmed by somatic cell hybrid analysis. The analysis was based on the presence of a CK-2-alpha-specific 20-kb fragment. However, the CK-2 alpha cDNA hybridizes to several additional fragments in total human DNA. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
