Effects of some tricyclic psychopharmacons and structurally related compounds on motility ofProteus vulgaris |
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| Authors: | J Molnár J Ren J E Kristiansen M J Nakamura |
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| Institution: | (1) Institute of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary;(2) Laboratory Center, The Provincial Hospital of Shaanxi, Xian, China;(3) Department of Antibiotics, Statens Seruminstitut, Artillerivej 5, DK-2300 Copenhagen S., Denmark;(4) Department of Microbiology, University of Montana, Missoula, Montana, USA |
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| Abstract: | A simple test for the evaluation of drugs interfering with bacterial motility was established withProteus vulgaris. With this model, promethazine, 7-hydroxy-chlorpromazine, imipramine, 7,8-dioxochlorpromazine and acridine orange were shown to exert significant motility and swarming inhibitory action onProteus vulgaris strains at subinhibitory concentrations. Quinidine enhanced the antimotility effect of promethazine. The antimotility effect of promethazine was synergized by proton pump inhibitors omeprazole and abscissic acid, but antagonized by extracellular potassium and sodium ions. |
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| Keywords: | phenothiazines inhibition bacterial motility proton pump antagonism Proteus vulgaris |
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