TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC) |
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| Authors: | Wenyu?Jia Zequn?Li Junyu?Chen Lei?Sun Chuanqian?Liu Shaping?Wang Jingwei?Chi Jun?Niu Email authorView author&#;s OrcID profile" target="_blank">Hong?LaiEmail authorView author&#;s OrcID profile |
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| Institution: | 1.Department of Endocrinology,Shandong Provincial Hospital Affiliated to Shandong University,Jinan,People’s Republic of China;2.Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine,Jinan,People’s Republic of China;3.Department of General Surgery,Affiliated Hospital of Qingdao University,Qingdao,People’s Republic of China;4.Department of Endocrinology,Qilu Hospital of Shandong University,Jinan,People’s Republic of China;5.Department of Traditional Chinese Medicine,The First People’s Hospital of Jining,Jining,People’s Republic of China;6.Clinical Laboratory,Weihai Wendeng Central Hospital,Weihai,People’s Republic of China;7.Key Laboratory of Thyroid Disease,Affiliated Hospital of Qingdao University,Qingdao,People’s Republic of China;8.Department of General Surgery,Qilu Hospital of Shandong University,Jinan,People’s Republic of China |
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| Abstract: | BackgroundTumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a newly described negative immune regulator and is closely associated with various tumors. However, the expression and roles of TIPE2 in PTC is unknown.ResultsIn the present study, TIPE2 upregulation in PTC tissues was found to be negatively associated with tumor size, capsule infiltration, peripheral infiltration and tumor T stage, which could be used to predict tumor invasiveness. TIPE2 overexpression significantly suppressed the viability, proliferation, migration and invasion of PTC cells. Moreover, TIPE2 suppressed tumor invasiveness by inhibiting Rac1, leading to decreased expression of uPA and MMP9.ConclusionsThese results indicate that TIPE2 is a potential biomarker for predicting tumor aggressiveness and suppresses tumor invasiveness in a Rac1-dependent manner. |
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