Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty |
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| Authors: | Gonen Ozsarlak-Sozer Zeliha Kerry Goksel Gokce Ismail Oran Zeki Topcu |
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| Institution: | (1) Department of Pharmacology, Ege University, 35100 Izmir, Turkey;(2) Department of Radiology, Faculty of Medicine, Ege University, 35100 Izmir, Turkey;(3) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Ege University, 35100 Izmir, Turkey; |
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| Abstract: | Telomeres are specialized DNA–protein complexes found at the tips of linear chromosomes. In this study, we investigated the
effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon
injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress
increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence
on mean telomeric length distribution. |
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