The thrombospondin-4 gene |
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Authors: | Gail Newton Stanislawa Weremowicz Cynthia C Morton Nancy A Jenkins Debra J Gilbert Neal G Copeland Jack Lawler |
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Institution: | (1) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Research North (RN-270C), 99 Brookline Avenue, Boston, Massachusetts 02215, USA, US;(2) Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA, US;(3) Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA, US;(4) Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA, US |
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Abstract: | Thrombospondins are a family of extracellular, adhesive proteins that are widely expressed in vertebrates. Five distinct
gene products, designated thrombospondin-1 through -4 and cartilage oligomeric matrix protein (COMP), have been identified.
With the exception of thrombospondin-4, the structure and location of thrombospondin genes have been determined in the human
and/or mouse genomes. In this study, the structure and location of the murine thrombospondin-4 gene and the location of the
human thrombospondin-4 gene are reported. The murine thrombospondin-4 gene is approximately 4.5 kb in length and includes
22 exons. Interspecific backcross analysis of progeny derived from matings of (C57BL/6J ×Mus spretus)F1× C57BL/6J mice indicates that the thrombospondin-4 gene is tightly linked to the Dhfr locus on murine Chromosome (Chr) 13. The human gene maps to Chr 5 in band q13 by in situ hybridization to human metaphase
chromosomes. The thrombospondin-4 promoter is similar to promoters of some housekeeping, growth control, and other thrombospondin
genes in that it contains multiple GC box sequences and lacks a CAAT box. The presence of multiple E-box sequence motifs is
consistent with thrombospondin-4 expression in muscle and bone tissue.
Received: 18 May 1998 / Accepted: 24 May 1999 |
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