Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures |
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| Authors: | Ruth Farkas Shlomo Ben-Efraim Yosef Manor Israel Zan-Bar Abraham Klajman |
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| Institution: | (1) Laboratory for Clinical Immunology, Meir Hospital, 44 281 Kfar-Saba, Israel;(2) Department of Human Microbiology, Meir Hospital, Kfar-Saba, Israel;(3) Department of Hematology, Meir Hospital, Kfar-Saba, Israel;(4) Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel |
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| Abstract: | Summary Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity. |
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| Keywords: | T cell CD8 marker B cell leukemia |
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