Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA |
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| Authors: | E I Frolova E M Ivanova V F Zarytova T V Abramova V V Vlassov |
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| Affiliation: | Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk. |
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| Abstract: | Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs. |
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