Hox genes: realising the importance of realisators |
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Authors: | Lohmann Ingrid |
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Institution: | Max-Planck-Institute for Developmental Biology, Department for Molecular Biology, Spemannstrasse 37-39, 72076 Tübingen, Germany. ilohmann@tuebingen.mpg.de |
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Abstract: | A recent study for the first time unravels a complete Hox regulatory network sufficient for the specification of a simple organ in Drosophila, linking Hox output to one specific group of executive genes, the realisators. As these genes have a direct effect on cellular functions and are required in most cell types, Hox genes may ultimately execute their function in controlling segmental fate by fine-tuning the spatial and temporal expression levels of these realisators. |
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