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Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels |
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| Authors: | Mortell Kathleen H Anderson David J Lynch James J Nelson Sherry L Sarris Kathy McDonald Heath Sabet Reza Baker Scott Honore Prisca Lee Chih-Hung Jarvis Michael F Gopalakrishnan Murali |
| Affiliation: | Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com |
| Abstract: | A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described. |
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