Role of environmental factors in autoantibody production - importance of a detailed analysis in a small cohort |
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Authors: | Minoru Satoh Angela Ceribelli Edward KL Chan |
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Institution: | (1) Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P.O. Box 100221, Gainesville, FL 32610-0221, USA;(2) Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, P.O. Box 100221, Gainesville, FL 32610-0221, USA;(3) Department of Oral Biology, University of Florida, Gainesville, FL 32610-0424, USA |
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Abstract: | In the previous issue of Arthritis Research & Therapy, Muro and colleagues reported a detailed epidemiologic analysis in central Japan on one of the new myositis-specific autoantibodies
to MDA-5 (melanoma differentiation-associated gene 5), which is associated with clinically amyopathic dermatomyositis accompanying
interstitial lung disease. The increasing prevalence of anti-MDA-5, higher prevalence in small rural towns, and geographical
clustering in two areas along the Kiso River suggest a role of environmental factors associated with rural communities or
the river/water system or both. A detailed analysis of a small cohort may offer clues, which is ignored in multi-center studies,
to the pathogenesis of systemic rheumatic diseases and autoantibody production. |
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