Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy |
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| Authors: | Martinez Micaela Ono Nadia Planutiene Marina Planutis Kestutis Nelson Edward L Holcombe Randall F |
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| Institution: | (1) Division of Hematology/Oncology, University of California, Irvine, CA, USA;(2) Tisch Cancer Institute of Mt. Sinai School of Medicine, New York, NY, USA |
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| Abstract: | Background Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients
receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. |
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