|
|||||
|
|
Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism |
|
| Authors: | Meredith R McGuire Debaditya Mukhopadhyay Stephanie L Myers Eric P Mosher Rita T Brookheart Kai Kammers Alfica Sehgal Ebru S Selen Michael J Wolfgang Namandj N Bumpus Peter J Espenshade |
| Institution: | 1.Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;2.Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;3.Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;4.Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA |
| Abstract: | |
| Keywords: | cytochrome P450 heme enzyme degradation drug metabolism liver metabolism protein turnover |