Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism |
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| Authors: | Meredith R. McGuire,Debaditya Mukhopadhyay,Stephanie L. Myers,Eric P. Mosher,Rita T. Brookheart,Kai Kammers,Alfica Sehgal,Ebru S. Selen,Michael J. Wolfgang,Namandjé N. Bumpus,Peter J. Espenshade |
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| Affiliation: | 1.Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;2.Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;3.Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;4.Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA |
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| Abstract: | |
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| Keywords: | cytochrome P450 heme enzyme degradation drug metabolism liver metabolism protein turnover |
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