Unusual production of glutathione in Actinobacteria |
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| Authors: | Todd Johnson Gerald L. Newton Robert C. Fahey Mamta Rawat |
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| Affiliation: | (1) Department of Biology, California State University-Fresno, Fresno, CA, 93740, USA;(2) Department of Chemistry and Biochemistry, The University of California at San Diego, San Diego, USA |
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| Abstract: | Most Actinobacteria produce mycothiol as the major thiol. In addition to mycothiol Rhodococcus AD45 generates a substantial level of glutathione possibly using genes acquired in a lateral transfer. Instead of mycothiol, Rubrobacter radiotolerans and Rubrobacter xylanophilus produce glutathione, whose synthesis appears to involve enzymes substantially different from those in other organisms. |
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| Keywords: | Mycothiol Actinomycetes Glutathione Rubrobacter Rhodococcus |
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