Simple and efficient synthesis of chiral amino alcohols with an amino acid-based skeleton |
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Authors: | Paulina Juszczyk Regina Kasprzykowska Aleksandra S. Koodziejczyk |
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Affiliation: | (1) Faculty of Chemistry, University of Gdask, Sobieskiego 18, 80–952 Gdask, Poland |
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Abstract: | Sodium bis(2-methoxyethoxy)aluminum hydride, NaAlH2(OCH2CH2OCH3)2, commercially known as Vitride® or Red-Al®, enables rapid synthesis of pure optically active N-protected amino alcohols and peptide alcohols in very high yields. The method is very simple and attractive, as it does not require an additional step of N-protected amino acid derivatization and proceeds without the loss of enantiomeric homogeneity. |
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Keywords: | 1 2-aminoalcohols amino acid reduction vicinal amino alcohols vitride |
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