The effect of electron and gamma irradiation on the induction of micronuclei in cytokinesis-blocked human blood lymphocytes |
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| Authors: | Santhosh Acharya Ganesh Sanjeev N N Bhat K Siddappa Y Narayana |
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| Institution: | (1) Microtron Centre, Department of Studies in Physics, Mangalore University, Mangalagangotri, Mangalore, 574199, India;(2) Radiological Physics and Advisory Division, Bhabha Atomic Research Centre (BARC), Mumbai, India;(3) JSS Foundation for Science and Society, Bangalore, India |
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| Abstract: | The effect of electrons and gamma irradiation on the induction of micronuclei in cytokinesis-blocked human peripheral blood
lymphocytes was investigated to understand the relative biological effectiveness (RBE) of electrons compared with gamma rays.
Blood samples were irradiated with an 8 MeV pulsed electron beam, at a mean instantaneous dose rate of 2.6 × 105 Gy s−1. Gamma irradiation was carried out at a dose rate of 1.98 Gy min−1 using 60Co gamma source. A dose-dependent increase in micronuclei yield was observed. The dose–response relationships for induction
of micronuclei fitted well to a linear–quadratic relationship and the coefficients α and β of the dose–response curve were
estimated by fitting the data using error-weighted minimum χ
2 method. The RBE of 8 MeV electrons were found to be near unity as compared with gamma rays. |
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