Factors enhancing lycopene production by a new Mycobacterium aurum mutant |
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Authors: | S Kerr C Calé JMS Cabral F van Keulen |
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Institution: | University College London, Gower Street, London WC1E6BT, UK. |
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Abstract: | A mutant strain of Mycobacterium aurum was isolated that produced mainly lycopene (>80%) with a total carotenoid content of 1.2 mg g(-1) dry biomass when grown on yeast extract and glucose. Lycopene content of the cells could be significantly increased, up to 7.4 mg g(-1) biomass, by growing the cells at suboptimal initial culture pH (pH 6-6.4) or by using high salt concentration (85 mM NaCl) in the culture medium, although a 25-40% decrease in biomass production occurred in both cases. Highestproductivity (4 mg lycopene l(-1) d(-1)) was obtained by cultivating the cells at pH 6. |
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Keywords: | carotenoids lycopene medium optimisation Mycobacterium aurum stress |
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