A nearby inverted repeat of the terminal sequence of herpes simplex virus DNA. |
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| Authors: | R W Hyman S Burke L Kudler |
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| Institution: | Department of Microbiology The Milton S. Hershey Medical Center The Pennsylvania State University College of Medicine Hershey, Pennsylvania 17033 USA |
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| Abstract: | When herpes simplex virus DNA is digested with λ-exonuclease, annealed, and then mounted for observation in the electron microscope, two types of molecules are seen. One type is circular DNA which forms because the enzyme has revealed the terminal repetition. The other type is full length linear duplex DNA with a short single-stranded loop on one end. This latter type, which apparently represents a fold-back reaction, forms because there is a nearby inverted repeat of the terminal sequence of herpes simplex virus DNA. |
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