Effect of dimethyl sulfoxide on lysine production by a mutant ofBacillus subtilis with low homoserine dehydrogenase activity |
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| Authors: | H. O. Kalcheva V. O. Shanskaya J. Smutny S. S. Maluta |
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| Affiliation: | (1) Institute of Molecular Biology and Genetics, Kiev, USSR;(2) Institute of Animal Physiology, Košice, Czechoslovakia |
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| Abstract: | SomeBacillus subtilis mutants with different levels of homoserine dehydrogenase were described. Strains that do not accumulate methionine have a high homoserine dehydrogenase activity. Low activity was detected in mutants where cell growth was completely inhibited by 0.7 mmol/L methionine. A low concentration of dimethyl sulfoxide had a stimulatory effect on lysine production by the methionine-sensitive mutant ofBacillus subtilis. |
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