Pyrrolidine carbamate nucleic acids: synthesis and DNA binding studies |
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Authors: | Meena Kumar Vaijayanti A |
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Affiliation: | Division of Organic Chemistry (Synthesis), National Chemical Laboratory, 411008, Pune, India. |
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Abstract: | An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as nitrophenyl carbonates for the synthesis of dimer, trimer and oligomers. |
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