Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis |
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Authors: | Vanoosthuyse Vincent Hardwick Kevin G |
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Affiliation: | Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK. vvanoost@staffmail.ed.ac.uk |
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Abstract: | To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process. |
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