The macrocyclic effect and vasodilation response based on the photoinduced nitric oxide release from trans-[RuCl(tetraazamacrocycle)NO](2+) |
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Authors: | Oliveira Fabiana de Souza Ferreira Kleber Queiroz Bonaventura Daniella Bendhack Luziane M Tedesco Antonio Claudio Machado Sergio de P Tfouni Elia da Silva Roberto Santana |
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Institution: | Faculdade de Ciências Farmacêuticas de Ribeir?o Preto, USP, Av do Café s/n, Ribeir?o Preto CEP 14040-903, SP, Brazil. |
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Abstract: | Irradiation of trans-RuCl(cyclam)(NO)](2+), cyclam is 1,4,8,11-tetraazacyclotetradecane, at pHs 1-7.4, with near UV light results in the release of NO and formation of trans-Ru(III)Cl(OH)(cyclam)](+) with pH dependent quantum yields (from approximately 0.01 to 0.16 mol Einstein(-1)) lower than that for trans-RuCl(15]aneN(4))(NO)](2+), 15]aneN(4) is 1,4,8,12-tetaazacyclopentadecane, (0.61 mol Einstein(-1)). After irradiation with 355 nm light, the trans-RuCl(15]aneN(4))(NO)](2+) induces relaxation of the aortic ring, whereas the trans-RuCl(cyclam)(NO)](2+) complex does not. The relaxation observed with trans-RuCl(15]aneN(4))(NO)](2+) is consistent with a larger quantum yield of release of NO from this complex. |
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Keywords: | Nitrosyl ruthenium complexes Nitric oxide Macrocycle Tetraazamacrocycle Photochemistry |
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