Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney

Summary The polypeptide LTW-4 has previously been shown by 2D electrophoresis to be a major soluble protein of mouse liver. We now show that it is a major soluble polypeptide of mouse kidney. The Ltw-4 locus has been mapped on Chromosome 1 using the BXD, AKXL and BXH recombinant inbred strains. The gene order is Dip-1-Rnr-(Sas-1, ald)-Ltw-4-Mls. The map distance between (Dip-1, Rnr) and Ltw-4 is estimated to be 12.2±4.2 cM, between Sas-1 and Ltw-4 5.4±2.6, between ald and Ltw-4 7.1±4.6 cM, and between Ltw-4 and Mls 4.3±2.0 cM. The strain distribution pattern of Ltw-4 is reported for the SWXL recombinant inbred strains and for a large number of inbred strains of mice.