| CXXC4、EZH2在口腔鳞状细胞癌中表达及临床意义 |
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| 引用本文： | 钟克涛,静广平,田 兵,俞 晴,王海涛,胡腾龙.CXXC4、EZH2在口腔鳞状细胞癌中表达及临床意义[J].现代生物医学进展,2019,19(4):676-679. |
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| 作者姓名： | 钟克涛 静广平 田 兵 俞 晴 王海涛 胡腾龙 |
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| 作者单位： | 哈尔滨医科大学口腔医学院口腔外科二病房 |
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| 基金项目： | 黑龙江省应用技术与开发计划项目（GA14C101-10） |
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| 摘 要： | 目的:探讨口腔鳞状细胞癌(Oral Squamous Cell Carcinoma,OSCC)中CXXC指蛋白4(CXXC finger protein 4,CXXC4)与Zeste基因增强子同源物2(Enhancer of zeste homolog 2,EZH2)的表达、相关性及与临床病理特征之间的关系,为OSCC的早期诊断、治疗、判断预后及预防等提供参考依据。方法:采用免疫组织化学S-P法检测CXXC4蛋白及EZH2蛋白在60例口腔鳞状细胞癌组织及20例非肿瘤患者正常口腔黏膜组织中的表达情况,分析二者与口腔鳞状细胞癌临床病理特征的相关性。结果:口腔鳞状细胞癌组织中CXXC4蛋白的表达率为35.0%(21/60),明显低于正常口腔黏膜组织的60.0%(12/20)(P0.05);口腔鳞状细胞癌中EZH2蛋白的表达率为70.0%(42/60),高于正常口腔黏膜组织的25%(5/20)(P0.05)。CXXC4蛋白与EZH2蛋白的表达与口腔鳞状细胞癌的病理分化程度、TNM分期及淋巴结转移等密切相关(P0.05),而与年龄、性别及肿瘤直径大小等无关。CXXC4蛋白与EZH2蛋白在OSCC中表达呈负相关(r=-0.511,P0.001)。结论:CXXC4蛋白的表达下调或缺失以及EZH2蛋白的表达上调或过表达与口腔鳞状细胞癌的发生、发展及侵袭转移有关,可能作为口腔鳞状细胞癌预后预测的参考指标。
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| 关 键 词： | 口腔鳞状细胞癌 CXXC4 EZH2 |
| 收稿时间： | 2018/4/8 0:00:00 |
Expressions and Clinical Significances of CXXC4 and EZH2 in the Oral Squamous Cell Carcinoma |
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| ZHONG Ke-tao,JING Guang-ping,TIAN Bing,YU Qing,WANG Hai-tao and HU Teng-long.Expressions and Clinical Significances of CXXC4 and EZH2 in the Oral Squamous Cell Carcinoma[J].Progress in Modern Biomedicine,2019,19(4):676-679. |
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| Authors: | ZHONG Ke-tao JING Guang-ping TIAN Bing YU Qing WANG Hai-tao and HU Teng-long |
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| Institution: | Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China,Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China,Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China,Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China,Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China and Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China |
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| Abstract: | |
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| Keywords: | Oral Squamous Cell Carcinoma CXXC4 EZH2 |
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