脂联素在早产儿血清中的表达及其与体格指标、载脂蛋白和骨密度的关系

目的:探讨脂联素在早产儿血清中的表达水平及其与体格指标、载脂蛋白和骨密度的相关性。方法:选择2017年1月至2018年5月期间我院新生儿科住院的早产儿72例作为研究组,另外选择同期我院出生的足月新生儿58例作为对照组。对比两组新生儿的一般资料、脂联素、载脂蛋白和骨密度水平,分析早产儿血清脂联素水平与体格指标、载脂蛋白和骨密度的相关性,同时分析影响血清脂联素水平的危险因素。结果:两组受试新生儿的性别、胸围、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)之间的差异无统计学意义(P0.05);研究组新生儿的胎龄、体质量指数(BMⅠ)、身长、头围、总胆固醇(TC)及三酰甘油(TG)明显低于对照组(P0.05);与对照组相比,研究组新生儿血清脂联素、载脂蛋白A-Ⅰ(Apo A-Ⅰ)及左胫骨中段超声波在骨骼中的传播速度(SOS)水平明显下降,而载脂蛋白B(Apo B)和Apo B/Apo A-Ⅰ水平均显著升高,且差异均具有统计学意义(P0.05);早产儿血清脂联素水平与胎龄、BMⅠ、头围、TC、TG、Apo A-Ⅰ及SOS呈正相关(P0.05),与Apo B和Apo B/Apo A-Ⅰ水平呈负相关(P0.05);Logistic回归结果显示,胎龄、BMⅠ、Apo B/Apo A-Ⅰ及SOS是早产儿血清脂联素水平的影响因素(P0.05)。结论:早产儿血清脂联素水平低于足月儿,血清脂联素水平与体格指标、载脂蛋白及骨密度密切相关,可能对新生儿的生长发育具有重要的调节作用。

Expression of Serum Adiponectin in Premature Infants and Its Relationship with Body Mass Index, Apolipoprotein and Bone Mineral Density

ABSTRACT Objective: To explore the expression of serum adiponectin in premature infants and its correlation with body mass in- dex, apolipoprotein and bone mineral density. Methods: A total of 72 premature infants, who were hospitalized in First Hospital of Hebei Medical University from January 2017 to May 2018 were chosen as research group. In addition, 58 neonatal infants born in this hospital during the same period were chosen as control group. The general data, adiponectin, apolipoprotein and bone mineral density of two groups of neonates were compared, the correlation between serum adiponectin level, body mass index, apolipoprotein and bone mineral density in the preterm infants were analyzed. Meanwhile, the risk factors of serum adiponectin level were analyzed. Results: There were no statistically significant differences in the gender, chest circumference, low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) between the two groups(P>0.05). The gestational age, body mass index (BMI), body length, head circumference, total choles- terol (TC) and three acylglycerol(TG) in the research group were significantly lower than those in the control group (P<0.05). Compared with the control group, the serum adiponectin, apolipoprotein A-I (Apo A-I) and the middle segment of the left tibia in the research group decreased significantly in the bone transmission speed(SOS), while the apolipoprotein B (Apo B) and Apo B/Apo A-I levels increased significantly, and the differences were statistically significant(P<0.05). The serum adiponectin level in premature infants was positively correlated with gestational age, BMI, head circumference, TC, TG, Apo A-I and SOS(P<0.05), and which was negatively correlated with Apo B and Apo B/Apo A-I(P<0.05). Logistic regression results showed that gestational age, BMI, Apo B/Apo A-I and SOS were the in- fluencing factors of serum adiponectin level in the premature infants(P<0.05). Conclusion: The level of serum adiponectin of preterm in- fant is lower than mature infants, and serum adiponectin level is closely related to the body mass index, apolipoprotein and bone mineral density, which may play an important role in the regulation of newborn growth and development.