| 不同浓度右美托咪定对低血红蛋白全麻患者脑氧饱和度的影响 |
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| 引用本文： | 黄 昕,杨延超,滕秀飞,万玉骁,李 阳,魏 巍,李秀艳,刘诗煜,史胜哲,朱俊超. 不同浓度右美托咪定对低血红蛋白全麻患者脑氧饱和度的影响[J]. 现代生物医学进展, 2019, 19(2): 258-261 |
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| 作者姓名： | 黄 昕 杨延超 滕秀飞 万玉骁 李 阳 魏 巍 李秀艳 刘诗煜 史胜哲 朱俊超 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院麻醉科;中国医科大学附属盛京医院麻醉科 |
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| 基金项目： | 辽宁省自然科学基金项目（20102282） |
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| 摘 要： | 目的:探讨不同浓度右美托咪定(Dex)对低血红蛋白全麻患者脑氧饱和度(rSO_2)的影响。方法:选取行择期全麻开腹妇科手术、血红蛋白在8～9 g/dl的女性患者60例,根据不同浓度右美托咪定随机分为D1(0.1μg·kg~(-1)·h~(-1))、D2(0.3μg·kg~(-1)·h~(-1))、D3(0.5μg·kg~(-1)·h~(-1))以及C组(等量0.9%生理盐水组),每组15例。D1～D3组患者入室后于麻醉开始前均给予0.5μg·kg-1负荷剂量右美托咪定于15 min内泵入。四组麻醉诱导后,均行七氟醚复合瑞芬太尼静吸复合麻醉维持,D1～D3组泵入相应浓度剂量的右美托咪定,C组泵入等量的生理盐水,直至手术结束前40 min停止泵入。在诱导前开始记录患者以下变量基线值:平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO_2)、脑氧饱和度(rSO_2)、脑电双频指数(BIS)、以及腋温(T)。并在术中相对平稳期同样记录以上变量数值以及呼吸末二氧化碳浓度(P_(ET)CO_2),每3 min记录一次,共记录30 min。结果:四组患者入室后脑氧饱和度、平均动脉压、心率、指脉氧饱和度、腋温组间比较差异无统计学意义(P0.05)。与D1组比较、D2组脑氧饱和度较高;与D2组比较,D3组脑氧饱和度较高,差异有统计学意义(P 0.05)。在一定剂量范围内应用右美托咪定,可使低血红蛋白患者术中脑氧饱和度随泵入右美托咪定剂量的增加而增加,并且这一关系具有线性相关性(P0.05,相关系数r=0.9999)。结论:在一定剂量范围内应用右美托咪定可使低血红蛋白患者术中脑氧饱和度随应用右美托咪定剂量增加而增加,对于改善患者预后起着积极作用。
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| 关 键 词： | 脑氧饱和度；右美托咪定；血红蛋白；近红外光谱技术 |
| 收稿时间： | 2018-03-28 |
| 修稿时间： | 2018-04-25 |
Effect of Different Concentrations of Dexmedetomidine on the Cerebral Oxygen Saturation of Low Hemoglobin Patients under General Anesthesia |
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| HUANG Xin,YANG Yan-chao,TENG Xiu-fei,WAN Yu-xiao,LI Yang,WEI Wei,LI Xiu-yan,LIU Shi-yu,SHI Sheng-zhe and ZHU Jun-chao. Effect of Different Concentrations of Dexmedetomidine on the Cerebral Oxygen Saturation of Low Hemoglobin Patients under General Anesthesia[J]. Progress in Modern Biomedicine, 2019, 19(2): 258-261 |
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| Authors: | HUANG Xin YANG Yan-chao TENG Xiu-fei WAN Yu-xiao LI Yang WEI Wei LI Xiu-yan LIU Shi-yu SHI Sheng-zhe ZHU Jun-chao |
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| Affiliation: | Department of Anesthesiology, Union Hospital Affiliated to Tongji Medical college of Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China,Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China and Department of Anesthesiology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China |
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| Abstract: | |
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| Keywords: | Cerebral oxygen saturation Dexmedetomidine Hemoglobin concentration Near infrared spectroscopy |
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