| PKD1基因与抑癌基因P53多态性与非综合征性唇腭裂的关联研究 |
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| 引用本文： | 孟祥彪,刘廷廷,刘晓彤,陈春羽,回 翔,姜宇欣,焦晓辉,吕克文,宋 涛.PKD1基因与抑癌基因P53多态性与非综合征性唇腭裂的关联研究[J].现代生物医学进展,2019,19(3):556-559. |
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| 作者姓名： | 孟祥彪 刘廷廷 刘晓彤 陈春羽 回 翔 姜宇欣 焦晓辉 吕克文 宋 涛 |
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| 作者单位： | 哈尔滨医科大学口腔医院口腔颌面外科 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（#11551183） |
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| 摘 要： | 目的:探讨多囊性肾病基因1(polystic kidney disease,PKD1)多态位点rs8049367与抑癌基因P53(anti-oncogene P53)多态位点rs4791774单核苷酸多态性与中国北方人群非综合征性唇腭裂(NSCL/P)的相关性。方法:运用聚合酶链式反应-连接酶检测反应(PCR-LDR)的检测方法,对602例NSCL/P患者和510例对照人群的PKD1基因的rs8049367位点和抑癌基因P53的rs4791774位点进行基因分型。利用SPSS12.0软件分析PKD1基因,抑癌基因P53多态性与NSCL/P的相关性。结果:rs8049367位点和rs4791774位点基因型及基因频率在两组的分布中差异无统计学意义(P0.05)。结论:PKD1基因的rs8049367位点和抑癌基因P53的rs4791774位点单核苷酸多态性可能与中国北方人群非综合征性唇腭裂的发生无相关性。
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| 关 键 词： | PKD1基因 抑癌基因P53 基因多态性 非综合征性唇腭裂 相关性 |
| 收稿时间： | 2018/3/27 0:00:00 |
| 修稿时间： | 2018/4/23 0:00:00 |
Association between Pkd1, Anti-oncogene p53 Gene Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate |
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| MENG Xiang-biao,LIU Ting-ting,LIU Xiao-tong,CHEN Chun-yu,HUI Xiang,JIANG Yu-xin,JIAO Xiao-hui,LV Ke-wen and SONG Tao.Association between Pkd1, Anti-oncogene p53 Gene Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate[J].Progress in Modern Biomedicine,2019,19(3):556-559. |
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| Authors: | MENG Xiang-biao LIU Ting-ting LIU Xiao-tong CHEN Chun-yu HUI Xiang JIANG Yu-xin JIAO Xiao-hui LV Ke-wen and SONG Tao |
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| Institution: | Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China,Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China and Department of Stomatology, The first Affiliated Hospital, Harbin Medical Univercity, Harbin, Heilongjiang, 150001, China |
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| Abstract: | |
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| Keywords: | Polystic kidney disease Anti-oncogene p53 Genetic polymorphism Nonsydromic cleft lip with or without cleft palate Carrelation |
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