血清IL-2、IL-16水平的变化和艾滋病患者机会性感染的关系探究

目的:研究血清IL-2、IL-16水平的变化和艾滋病患者机会性感染的关系。方法:选择2016年1月至2018年10月在我院接受治疗的艾滋病患者120例作为观察组,根据美国疾病预防控制中心及世界卫生组织标准将其分为三期,A期24例,B期41例,C期55例,其中96例为机会性感染者。同期选择20例在本院进行正常体检者作为对照组。观察组采用高效抗逆转录病毒疗法(HAART)治疗。检测和比较各期艾滋病患者与对照组、机会性感染组与非机会性感染组、艾滋病各期治疗前后血清白介素-2(IL-2)、白介素-16(IL-16)、CD4~+细胞、CD8~+细胞计数的差异。结果:观察组各期艾滋病患者血清IL-2、IL-16水平明显低于对照组,且C期患者血清IL-2、IL-16水平均显著低于A、B期患者(P0.05);观察组及各期患者CD4~+细胞计数均低于对照组,CD8~+细胞计数均高于对照组,且C期患者CD4~+细胞计数均显著低于A、B期患者,CD8~+细胞计数均高于A、B期患者(P0.05);机会性感染组患者血清IL-2、IL-16水平明显低于非机会性感染组(P0.05);治疗后,观察组各期患者血清IL-2、IL-16水平较治疗前明显显著升高,且A期患者血清IL-2、IL-16显著高于B、C期患者(P0.05)。结论:艾滋病机会性感染患者血清IL-2、IL-16水平均显著降低,通过监测血清IL-2、IL-16水平可积极防治机会性感染。

elationship between the Levels of serum IL-2 and IL-16 and the Opportunistic Infection in HIV-infected Patients

ABSTRACT Objective: To study the relationship between changes of serum il-2 and il-16 and opportunistic infection in AIDS pa- tients. Methods: 120 patients with AIDS who received treatment in our hospital from January 2017 to October 2018 were selected as the observation group. According to the standards of the us centers for disease control and prevention and the world health organization, they were divided into three stages: 24 cases of stage A, 41 cases of stage B and 55 cases of stage C, among which 96 cases were opportunistic infection. During the same period, 20 cases of normal physical examination in our hospital were selected as the control group. The obser- vation group was treated with highly active antiretroviral therapy (HAART). To detect and compare the difference of serum interleukin-2 (il-2), interleukin-16 (il-16), CD4⁺ cells and CD8⁺ cells between AIDS patients and control group, opportunistic infection group and non-opportunistic infection group before and after treatment of AIDS. Results: The levels of serum il-2 and il-16 in the observation group were significantly lower than those in the control group, and the levels of serum il-2 and il-16 in the C group were significantly lower than those in the A and B groups (P<0.05). The CD4⁺ cell count of the observation group and patients at all stages was lower than that of the control group, and the CD8⁺ cell count was higher than that of the control group. The CD4⁺ cell count of patients at stage C was sig- nificantly lower than that of patients at stage A and B, and the CD8⁺ cell count was higher than that of patients at stage A and B (P<0.05). Serum il-2 and il-16 levels in the opportunistic infection group were significantly lower than those in the non-opportunistic infection group(P<0.05). After treatment, serum il-2 and il-16 levels of patients in the observation group were significantly higher than those before treatment, and serum il-2 and il-16 levels of patients in stage A were significantly higher than those in stage B and C(P<0.05). Conclusion: Serum il-2 and il-16 levels of AIDS patients with opportunistic infection were significantly reduced, and the monitoring of serum il-2 and il-16 levels can actively prevent and treat opportunistic infection.