透明质酸钠联合硫酸氨基酸葡萄糖钾胶囊对踝关节损伤患者血清骨性标志物水平及关节功能的影响

目的:探讨透明质酸钠联合硫酸氨基酸葡萄糖钾胶囊对踝关节损伤患者血清骨性标志物水平及关节功能的影响。方法:选择2015年1月至2017年1月在我院接受治疗的120例踝关节损伤患者,将其随机分为观察组和对照组,每组各60例。对照组患者采用透明质酸钠联治疗,观察组则在对照组治疗方案的基础上联合硫酸氨基酸葡萄糖钾胶囊进行治疗。检测和比较两组患者治疗前后血清骨钙素(BGP)、I型前胶原羧基端肽(PICP)、骨源性碱性磷酸酶(BALP)水平及Baird-Jackson踝关节评分的变化情况及治疗后的临床疗效。结果:治疗后,观察组的总有效率(91.67%)明显高于对照组(78.33%,P0.05)。两组患者治疗后的血清BGP、PICP、BALP水平及Baird-Jackson踝关节评分均较治疗前显著升高,且观察组明显高于对照组(P0.05)。两组治疗过程中均无明显不良反应发生。结论:透明质酸钠联合硫酸氨基酸葡萄糖钾胶囊治疗踝关节损伤患者的临床疗效显著优于单用透明质酸钠联治疗,其可有效改善血清骨性标志物水平,且利于踝关节功能的恢复。

Effect of Sodium Hyaluronate Combined with Glucosamine Sulfate Glucose Potassium on the Serum Osteo-Marker and Joint Function of Patients with Ankle Joint Injury

ABSTRACT Objective: To study the effect of sodium hyaluronate combined with glucosamine Sulfate Glucose Potassium capsule on the serum bilirubin level and joint function of patients with ankle joint injury. Methods: 120 cases of patients with ankle injuries treated in our hospital from January 2015 to January 2017 were selected and randomly divided into the observation group and the control group, with 60 cases in each group. The control group was treated with sodium hyaluronate, while the observation group was treated with glucosamine potassium sulfate capsules on the basis of treatment regimen of the control group. The changes of serum osteocalcin (BGP), type I precollagen carboxyl-terminated peptide (PICP), osteogenic alkaline phosphatase (BALP) and baird-jackson ankle score before and after treatment and the clinical efficacy were measured and compared between the two groups. Results: After treatment, the total effective rate of observation group (91.67%) was significantly higher than that of the control group (78.33%, P<0.05). The serum BGP, PICP, BALP and baird-jackson ankle scores of both groups were significantly increased after treatment compared with those before treatment, which were significantly higher in the observation group than those of the control group (P<0.05). No obvious adverse reactions occurred during the treatment in both groups. Conclusion: The clinical efficacy of sodium hyaluronate combined with glucosamine potassium sulfate is significantly better than that of sodium hyaluronate alone in the treatment of patients with ankle joint injury.