天麻素耳迷根穴位注射联合注射用鼠神经生长因子治疗耳鸣的疗效研究

目的:研究天麻素耳迷根穴位注射联合注射用鼠神经生长因子治疗耳鸣的临床效果及对患者血液流变学和临床症状体征的影响。方法:选择2017年2月～2018年2月我院收治的156例耳鸣患者,随机分为两组。对照组肌肉注射鼠神经生长因子,每次20μg,每天1次;观察组联合耳迷根穴位注射天麻素,每次2 m L,每天1次。两组均治疗4周后,比较两组的治疗有效率,治疗前后的血液流变学指标以及耳鸣对睡眠的影响、发生环境、持续时间、对情绪的影响、对生活和工作的影响以及患者的主观感觉等临床症状体征评分。结果:治疗后,观察组的治疗有效率为89.74%,显高于对照组(71.79%,P0.05)。两组治疗后的全血黏度低切、血细胞比容、全血黏度高切及血浆黏度均较治疗前显著降低,且观察组以上指标均显著低于对照组(P0.05)。两组治疗后耳鸣对睡眠的影响、发生环境、持续时间、对情绪的影响、对生活和工作的影响以及患者的主观感觉等临床症状体征评分均较治疗前明显降低,且观察组以上指标均显著低于对照组(P0.05)。结论:天麻素耳迷根穴位注射联合注射用鼠神经生长因子可以提高耳鸣患者的治疗效果,有效改善患者的血液流变学和临床症状。

Effect of Gastrodia Elata Root Injection Combined with Mouse Nerve Growth Factor on the Tinnitus Patients

ABSTRACT Objective: To investigate the effect of gastrodia elata root injection combined with mouse nerve growth factor on tinnitus patients. Methods: Selected 156 cases of patients with SAP who were treated in our hospital from February 2017 to February 2018, divided into two groups randomly. The rats in the control group were injected intramuscular injection of mouse nerve growth factor, 20 g each time, 1 times a day, and the observation group was injected with gastrodin at the point of auricular root, 2 mL each time, 1 times a day. At 4 weeks after treatment, the effective rate of treatment, the hemorheological indexes before and after treatment, and the clinical symptoms and signs scores of tinnitus on sleep, occurrence environment, duration, emotional impact, life and work, and subjective feelings of patients were compared. Results: After treatment, the effective rate of observation group was 89.74%, which was significantly higher than that of the control group (71.79%, P<0.05). The whole blood viscosity, blood cell volume, high blood viscosity and plasma viscosity of both groups after treatment were significantly lower than before treatment, and the above indicators in the observation group were significantly lower than the control group (P<0.05). The effects of tinnitus on sleep, the environment, duration, mood, life and work, and subjective perception of the patients were significantly lower than those before treatment,and the above indicators in the observation group were significantly lower than the control group (P<0.05). Conclusion: Gastrodia elata root injection combined with injection of mouse nerve growth factor can improve the therapeutic effect of tinnitus patients, and effectively improve the patient''s hemorheology and clinical symptoms.