| 长链非编码RNA HULC与消化系统肿瘤的相关性研究及作用机制* |
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| 引用本文： | 李正龙,李鑫恒,郑汪洋,李景林,王志东,姜兴明,崔云甫.长链非编码RNA HULC与消化系统肿瘤的相关性研究及作用机制*[J].现代生物医学进展,2019,19(1):193-196. |
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| 作者姓名： | 李正龙 李鑫恒 郑汪洋 李景林 王志东 姜兴明 崔云甫 |
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| 作者单位： | 哈尔滨医科大学附属第二医院胆胰外科 |
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| 基金项目： | 国家自然科学基金项目（81602088）；黑龙江省卫生计生委科研课题（2016-049）；黑龙江省博士后资助课题（LBH-Z16096）；哈尔滨医科大学创新科学研究基金项目（2016LCZX09） |
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| 摘 要： | 随着全基因组测序技术的快速发展,越来越多的长链非编码RNA(long noncoding RNA, lncRNA)分子被发现,逐渐成为新的研究热点。LncRNA HULC(highly up-regulated in liver cancer)是一种在肝癌中呈异常上调表达的长链非编码RNA,并参与调控了肝癌细胞增殖、抗凋亡、侵袭及上皮间质化等诸多肿瘤恶性生物学行为。随着研究的不断深入,发现HULC于其他消化系统肿瘤(胃癌、胰腺癌、结肠癌等)中同样呈现上调表达,可通过不同作用机制调控肿瘤的发生发展,并有望成为新型肿瘤诊断标志物和精准分子治疗的靶点。本文就近年来LncRNA HULC与消化系统肿瘤的相关性研究及其作用机制进行综述。
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| 关 键 词： | 长链非编码RNA HULC 消化系统肿瘤 调控机制 |
| 收稿时间： | 2017/12/26 0:00:00 |
| 修稿时间： | 2018/1/23 0:00:00 |
Research of Relevance and Regulatory Mechanisms of Long Non-coding RNA HULC in Digestive Neoplasms* |
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| LI Zheng-long,LI Xin-heng,ZHENG Wang-yang,LI Jing-lin,WANG Zhi-dong,JIANG Xing-ming and CUI Yun-fu.Research of Relevance and Regulatory Mechanisms of Long Non-coding RNA HULC in Digestive Neoplasms*[J].Progress in Modern Biomedicine,2019,19(1):193-196. |
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| Authors: | LI Zheng-long LI Xin-heng ZHENG Wang-yang LI Jing-lin WANG Zhi-dong JIANG Xing-ming and CUI Yun-fu |
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| Affiliation: | Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China,Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150087, China,Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150088, China,Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150089, China,Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150090, China,Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150091, China and Department of Hepatopancreaticobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150092, China |
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| Abstract: | |
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| Keywords: | Long non-coding RNA Highly up-regulated in liver cancer Digestive neoplasm Regulatory mechanism |
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