唑来膦酸注射液联合经皮椎体成形术治疗脊柱多发性骨髓瘤的临床疗效

目的:观察脊柱多发性骨髓瘤行唑来膦酸注射液与经皮椎体成形术联合治疗的临床疗效。方法:2010年8月至2017年3月,16例行多发性骨髓瘤患者接受经皮椎体成形术与唑来膦酸注射液联合治疗,评定疗效、疼痛缓解及治疗前后血碱性磷酸酶、血清钙、生活质量,记录不良反应。结果:(1)疗效:完全缓解1例,部分缓解12例,微小缓解1例,疾病进展1例,无变化1例,总有效率为87.5%(14/16)。(2)疼痛缓解:显效9例,有效6例,无效1例。总有效率93.75%(15/16)。(3)血碱性磷酸酶、血清钙、生活质量:治疗后优于治疗前(P0.05)。(4)研究期间不良反应轻微。结论:脊柱多发性骨髓瘤行唑来膦酸注射液与经皮椎体成形术联合治疗有助于缓解疼痛和改善生活质量。

Clinical Efficacy of Zoledronic Acid injection Combined with Percutaneous Vertebroplasty in the Treatment of Multiple Myeloma of Spine

ABSTRACT Objective: To observe the clinical effect of zoledronic acid injection combined with percutaneous vertebroplasty for multiple myeloma of spine. Methods: From August 2010 to March 2017, 16 patients with column multiple myeloma underwent percutaneous vertebroplasty combined with zoledronic acid injection. The efficacy, pain relief, blood alkaline phosphatase, serum calcium and quality of life were evaluated before and after treatment, and adverse reactions were recorded. Results: Curative effect: complete remission in 1 case, partial remission in 12 cases, minor remission in 1 case, disease progression in 1 case, no change in 1 case, the total effective rate was 87.5% (14/16). (2) Pain relief: 9 cases were markedly effective, 6 cases were effective and 1 case was ineffective. The total effective rate was 93.75% (15/16). Blood alkaline phosphatase, serum calcium and quality of life were better after treatment than before treatment (P<0.05). (5) The adverse reactions were mild during the study. Conclusion: Zoledronic acid injection combined with percutaneous vertebroplasty can relieve pain and improve the quality of life in multiple myeloma of spine.