| 变应性鼻炎发病机制研究的新进展 |
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| 引用本文： | 续 珊,陈始明,焦沃尔,邹 游,黄茂凌,申丽君. 变应性鼻炎发病机制研究的新进展[J]. 现代生物医学进展, 2019, 19(6): 1180-1183 |
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| 作者姓名： | 续 珊 陈始明 焦沃尔 邹 游 黄茂凌 申丽君 |
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| 作者单位： | 武汉大学人民医院耳鼻咽喉头颈外科;武汉大学人民医院耳鼻咽喉头颈外科研究所 |
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| 基金项目： | 国家自然科学基金项目（81770981） |
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| 摘 要： | 变应性鼻炎是特应性个体接触过敏原后由Ig E介导的I型超敏反应,以鼻腔粘膜为主要效应部位。在此过程中多种炎性细胞(辅助T细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞等)及细胞因子(IL-4、IL-5、IL-25、IL-33等)构成复杂的网络相互作用,共同促进了AR的发生发展。临床上传统药物治疗及过敏原特异性免疫疗法均有一定的局限性,本文通过对参与过敏性鼻炎发病机制的各个细胞及相关细胞因子的研究进展进行梳理,希望从中发掘出治疗AR的新思路和新靶点。
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| 关 键 词： | 变应性鼻炎 免疫学；上皮细胞；淋巴细胞；细胞因子 |
| 收稿时间： | 2018-04-28 |
| 修稿时间： | 2018-05-24 |
Recent Advances in Pathogenesis of Allergic Rhinitis |
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| XU Shan,CHEN Shi-ming,JIAO Wo-er,ZOU You,HUANG Mao-ling and SHEN Li-jun. Recent Advances in Pathogenesis of Allergic Rhinitis[J]. Progress in Modern Biomedicine, 2019, 19(6): 1180-1183 |
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| Authors: | XU Shan CHEN Shi-ming JIAO Wo-er ZOU You HUANG Mao-ling SHEN Li-jun |
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| Affiliation: | Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China,1 Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China; 2 Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China,Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China,Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China,Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China and Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China |
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| Abstract: | |
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| Keywords: | Allergic rhinitis Immunology Epithelial Cells Lymphocytes Cytokine |
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