乳腺癌超声征象与ER、PR、连环蛋白p120、癌基因CerbB-2、原癌基因Her-2/neu表达的关系研究

目的:探讨乳腺癌超声征象与雌激素受体(ER)、孕激素受体(PR)、连环蛋白p120、癌基因CerbB-2、原癌基因Her-2/neu表达的关系。方法:将2014年10月至2017年10月我院收治的50例乳腺癌患者纳入本研究,术前获得患者完整乳腺超声图像资料,术后通过免疫组织化学法检测ER、PR、CerbB-2、Her-2/neu和p120的表达情况。记录超声检查与组织标本检测结果,比较不同乳腺癌超声征象中ER、PR、CerbB-2、Her-2/neu和p120的表达情况。结果:p120阴性表达率为62.00%,ER阳性表达率为50.00%,PR阳性表达率为36.00%,CerbB-2阳性表达率为74.00%,Her-2/neu阳性表达率为30.00%。病灶边缘有毛刺征、周边有高回声晕征、无淋巴结转移患者的ER阳性表达率高于病灶边缘无毛刺征、周边无高回声晕征、淋巴结转移者(P0.05);病灶边缘有毛刺征、周边有高回声晕征患者的PR阳性表达率高于病灶边缘无毛刺征、周边无高回声晕征者(P0.05);内部有微小钙化、血流显像分级2-3级、淋巴结转移患者的p120阴性表达率高于内部无微小钙化、血流显像分级0-1级、无淋巴结转移者(P0.05);内部有微小钙化、血流显像分级2-3级、淋巴结转移患者的CerbB-2阳性表达率高于内部无微小钙化、血流显像分级0-1级、无淋巴结转移者(P0.05);内部有微小钙化、淋巴结转移患者的Her-2/neu阳性表达率高于内部无微小钙化、无淋巴结转移者(P0.05)。结论:乳腺癌超声征象与ER、PR、CerbB-2、Her-2/neu和p120的表达有紧密联系,可为治疗方案拟定提供参考。

The Correlation between the Ultrasonic Signs of Breast Cancer and the Expression of ER, PR, Catenin p120, oncogene CerbB-2 and Proto Oncogene Her-2/neu

ABSTRACT Objective: To explore the correlation between the ultrasonic signs of breast cancer and the expression of estrogen receptor (ER), progesterone receptor (PR), catenin p120, oncogene CerbB-2 and proto oncogene Her-2/neu. Methods: 50 patients with breast cancer who were treated in our hospital from October 2014 to October 2017 were included in this study. Complete breast ultrasound image data of patients were obtained before operation, and the expression of ER, PR, CerbB-2, Her-2/neu and p120 was detected by immunohistochemistry after operation. The results of ultrasonic examination and tissue specimen examination were recorded.The expression situation of ER, PR, CerbB-2, Her-2/neu, p120 were compared. Results: The negative expression rate of p120 was 62.00%, the positive expression rate of ER was 50.00%, the positive expression rate of PR was 36.00%, the positive expression rate of CerbB-2 was 74.00%, and the positive expression rate of Her-2/neu was 30.00%. The positive expression rate of ER in patients with marginal burrs sign around the edge of lesions, peripheral hyperechoic signs and without lymph node metastases was higher than that without marginal burrs sign around the edge of lesions, without peripheral hyperechoic signs and having lymph node metastases (P<0.05).The positive expression rate of PR in patients with marginal burrs sign around the lesion and high echo halo sign around the lesion was higher than that without marginal burrs sign around the lesion and without high echo halo sign around the lesion (P<0.05). The negative expression rate of p120 in patients with internal micro calcification, blood flow imaging grade 2-3 and lymph node metastasis was higher than that without internal micro calcification,without blood flow imaging grade 0-1 and without lymph node metastasis (P<0.05). The expression rate of CerbB-2 in patients with internal micro calcification, blood flow imaging grade 2-3 and lymph node metastasis was higher than that without internal micro calcification, without blood flow imaging grade 0-1 and without lymph node metastasis (P<0.05).The positive expression rate of Her-2/neu in patients with internal micro calcification and lymph node metastasis was higher than that without internal micro calcification and without lymph node metastases (P<0.05). Conclusion: The ultrasonic signs of breast cancer are closely related to the expression of ER, PR, CerbB-2, Her-2/neu and p120, which can provide a reference for the formulation of the treatment scheme.