Immobilisation stress-induced anorexia is not due to gastric ulceration |
| |
| Authors: | T P Donohoe G A Kennett G Curzon |
| |
| Affiliation: | 1. Servicio de Otorrinolaringología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda (Madrid), España;2. Servicio de Aparato Digestivo, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda (Madrid), España;1. Departamento de Gastroenterología, Vall d’Hebron Hospital Universitari, Vall d’Hebron, Barcelona, España;3. Departamento de Gastroenterología, Unidad de Motilidad Digestiva, Hospital Clínic, Barcelona, España;1. Service de psychopathologie de l’enfant et de l’adolescent, université de Picardie-Jules-Verne, CHU, avenue René-Laënnec, Salouel, 80054 Amiens, France;2. Unité de médecine de l’adolescent, CHU, avenue René-Laënnec, Salouel, 80054 Amiens, France;3. Unité de chirurgie pédiatrique, CHU, avenue René-Laënnec, Salouel, 80054 Amiens, France;1. Stockholm Centre for Eating Disorders, Stockholm, Sweden;2. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;3. Department of Surgery, Stockholm South General Hospital, Stockholm, Sweden;4. Department of Clinical Science and Education, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden;5. Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden |
| |
| Abstract: | The relationship between the anorexia following immobilisation and the associated gastric pathology in male and female rats was investigated. Male rats were injected with saline or the histamine-H2. antagonist, ranitidine, which inhibits gastric acid secretion but does not readily enter the brain. Thirty minutes later, the animals were immobilised for 2 hours. Ranitidine pretreatment reduced the number of gastric lesions but had no effect on the degree of stress-induced anorexia. The number of gastric lesions did not correlate significantly with the degree of anorexia or weight loss. Previous studies have reported that female rats (unlike males) exhibit anorexia after repeated daily immobilisations and have greater gastric pathology following stress. Therefore, in a second experiment, female rats were pretreated with saline or ranitidine and immobilised for 2 hours/day for 4 days. The drug did not decrease the number of lesions observed after this treatment. However, as in the first experiment, the number of lesions did not correlate significantly with anorexia or weight loss. It is therefore unlikely that immobilisation stress-induced anorexia in either male or female rats is merely a consequence of gastric ulceration. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
