Increased Plasma Levels of Brain Derived Neurotrophic Factor (BDNF) in Patients with Fibromyalgia |
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Authors: | Lisete Haas Luis V C Portela Ana Elisa Böhmer Jean Pierre Oses Diogo R Lara |
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Institution: | 1.Departamento de Ciências Fisiológicas, Faculdade de Biociências,Pontifícia Universidade Católica do Rio Grande do Sul,Porto Alegre,Brazil;2.Departamento de Bioquímica, ICBS,UFRGS,Porto Alegre,Brazil;3.Universidade Católica de Pelotas,Pelotas,Brazil |
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Abstract: | Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival and synaptic plasticity of the central and peripheral
nervous system. BDNF appears to modulate nociceptive sensory inputs and pain hypersensitivity and has been studied in pathological
situations, including chronic pain conditions and major depression. Increased serum BDNF levels have been recently reported
in fibromyalgia (FM). In the present study, we assessed plasma BDNF levels in patients with FM and controls. Plasma BDNF was
measured from 30 female patients with FM and 30 healthy age- and gender-matched volunteers using an enzyme immunoassay. FM
patients showed higher levels of BDNF (FM = 167.1 ± 171.2 pg/mL) when compared with the control group (control = 113.8 ± 149.6 pg/mL)
(P = 0.049; Mann–Whitney test). Six out of 30 controls presented superior values to the medium (15/15) of the patients with
fibromyalgia (129 pg/mL) (P = 0.029, Fisher exact test). There was no correlation between plasma BDNF levels and age, disease duration, pain score, number
of pain points and HAM-D score. Our results confirm previous findings of increased plasma BDNF levels in patients with FM,
suggesting that BDNF may be involved in the pathophysiology of Fibromyalgia, despite high levels of depression. |
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