Combination Treatment with Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells |
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Authors: | Hao Jiang Xia Shang Hongtao Wu Grace Huang Yiyang Wang Shaza Al-Holou Subhash C Gautam Michael Chopp |
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Institution: | (1) Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA;(2) Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA;(3) Department of Surgery, Henry Ford Hospital, Detroit, MI 48202, USA;(4) Department of Physics, Oakland University, Rochester Hills, MI 48309, USA |
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Abstract: | Resveratrol is a naturally occurring polyphenolic compound highly enriched in grapes, peanuts, red wine, and a variety of
food sources. Sulforaphane belongs to the family of isothiocyanates and is highly enriched in cruciferous vegetables. Our
previous study showed that resveratrol, when used at high concentrations, inhibited cell proliferation, caused the cell cycle
arrest and induced apoptotic cell death in glioma cells. In the current study, we tested the effect of combination treatment
with resveratrol and sulforaphane, when both were used at low concentrations, on cell proliferation, migration and death in
human U251 glioma cells. Our study shows that combination treatment with resveratrol and sulforaphane inhibits cell proliferation
and migration, reduces cell viability, induces lactate dehydrogenase release, decreases pro-survival Akt phosphorylation and
increases caspase-3 activation. The use of combination of bioactive food components, such as resveratrol and sulforaphane,
may be a viable approach for the treatment of glioma. |
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