Identification of NAD interacting residues in proteins |
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Authors: | Hifzur R Ansari Gajendra PS Raghava |
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Institution: | (1) Institute of Microbial Technology, Sector 39A, Chandigarh, 160036, India |
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Abstract: | Background Small molecular cofactors or ligands play a crucial role in the proper functioning of cells. Accurate annotation of their
target proteins and binding sites is required for the complete understanding of reaction mechanisms. Nicotinamide adenine
dinucleotide (NAD+ or NAD) is one of the most commonly used organic cofactors in living cells, which plays a critical role in cellular metabolism,
storage and regulatory processes. In the past, several NAD binding proteins (NADBP) have been reported in the literature,
which are responsible for a wide-range of activities in the cell. Attempts have been made to derive a rule for the binding
of NAD+ to its target proteins. However, so far an efficient model could not be derived due to the time consuming process of structure
determination, and limitations of similarity based approaches. Thus a sequence and non-similarity based method is needed to
characterize the NAD binding sites to help in the annotation. In this study attempts have been made to predict NAD binding
proteins and their interacting residues (NIRs) from amino acid sequence using bioinformatics tools. |
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