An <Emphasis Type="Italic">in vivo</Emphasis> RNA interference screen identifies gene networks controlling <Emphasis Type="Italic">Drosophila melanogaster</Emphasis>blood cell homeostasis |
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Authors: | Amélie Avet-Rochex Karène Boyer Cédric Polesello Vanessa Gobert Dani Osman Fernando Roch Benoit Augé Jennifer Zanet Marc Haenlin Lucas Waltzer |
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Institution: | 1.Université de Toulouse, UPS, CBD (Centre de Biologie du Développement),Toulouse,France;2.CNRS, CBD UMR5547,Toulouse,France;3.King's College London,London,UK |
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Abstract: | Background In metazoans, the hematopoietic system plays a key role both in normal development and in defense of the organism. In Drosophila,
the cellular immune response involves three types of blood cells: plasmatocytes, crystal cells and lamellocytes. This last
cell type is barely present in healthy larvae, but its production is strongly induced upon wasp parasitization or in mutant
contexts affecting larval blood cell homeostasis. Notably, several zygotic mutations leading to melanotic mass (or "tumor")
formation in larvae have been associated to the deregulated differentiation of lamellocytes. To gain further insights into
the gene regulatory network and the mechanisms controlling larval blood cell homeostasis, we conducted a tissue-specific loss
of function screen using hemocyte-specific Gal4 drivers and UAS-dsRNA transgenic lines. |
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