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Prokaryotic and eukaryotic integral membrane proteins have similar architecture |
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| Authors: | Rajneesh Kumar Gaur Girija Arun Natekar |
| Institution: | (1) Redox Biology Center, N118 Beadle Center, University of Nebraska, 1901 Vine Street, Lincoln, NE 68588-0662, USA;(2) Biosystems Laboratory, Chemical Engineering Department, Indian Institute of Technology, Bombay, Powai, Mumbai, 400076, India |
| Abstract: | Integral membrane proteins constitute a major constituent of lipid bilayer both in prokaryotes and eukaryotes. The statistical analysis was carried out to determine the bias in amino acid distribution between prokaryotic and eukaryotic integral membrane proteins (pIntMPs and eIntMPs). Our results indicate that both pIntMPs and eIntMPs demonstrate the striking similarity in amino acid distribution in their transmembrane and extramembranous region. pIntMPs have relatively greater functional importance for Gly and Asn in comparison to eIntMPs. |
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