微小RNA正调控基因表达的分子机制 |
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引用本文: | 刘宇辰[综述],蔡志明[审阅]. 微小RNA正调控基因表达的分子机制[J]. 国外医学:分子生物学分册, 2011, 0(3): 273-277,282 |
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作者姓名: | 刘宇辰[综述] 蔡志明[审阅] |
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作者单位: | [1]北京大学深圳医院深圳北京大学香港科技大学医学中心,广东省深圳市518036 [2]汕头大学医学院,广东省汕头市515041 [3]深圳市第二人民医院,广东省深圳市518036 |
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基金项目: | 广东省医学科研基金(No.B2009614) |
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摘 要: | microRNAs(miRNAs)是近年来发现的普遍存在于动植物体内的一类非编码RNA,传统观点认为,它们通过其种子序列定位于靶mRNA的3′非编码区,并发挥抑制靶mRNA翻译的作用.最新的研究揭示少数miRNAs也可以活化翻译,且这些现象的发生均与miRNA和翻译调控元件的相互作用有关.这些发现进一步扩展了对微小RNA功能的认识领域.
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关 键 词: | microRNAs 负调控 正调控 活化翻译 |
Positive-Regulation of Gene Expression by MicroRNA |
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Affiliation: | LIU Yuchen(1Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong, 518036, China 2 Shantou University Medical College, Shantou, Guangdong , 515041, China 3 Shenzhen Second Hospital, Shenzhen, Guangdong , 518036, China) |
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Abstract: | MicroRNAs (miRNAs) are a recently found class of non-coding RNAs and widely exist in plants and animals. In general, miRNAs play a negative role in regulation of gene translation by binding to the 3 UTR of target mRNA. Recent reports have indicated that some miRNAs can also activate translation. This up-regulation of gene expression by miRNAs has been found to be related to the interaction between miRNA and translational control elements. |
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Keywords: | microRNAs negative-regulation positive-regulation activate |
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