| 聚合物囊泡在生物医学领域中的应用 |
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| 引用本文： | 吴丽媛,牟颖,施维. 聚合物囊泡在生物医学领域中的应用[J]. 国外医学:分子生物学分册, 2011, 0(5): 443-446 |
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| 作者姓名： | 吴丽媛 牟颖 施维 |
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| 作者单位： | [1]吉林大学分子酶学工程教育部重点实验室,长春市130012 [2]浙江大学工业控制技术国家重点实验室智能系统与控制研究所分析仪器研究中心,杭州市310058 |
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| 基金项目： | 资助项目：科技部创新方法工作（No.2008IM040800）,苏州市科技计划（No.ZXG0920） |
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| 摘 要： | 聚合物囊泡是近年来新兴的一种自组装软性纳米材料。由于其优越的理化性质，聚合物囊泡已经受到了巨大的关注并且已经被利用在多个领域。文章综述了聚合物囊泡作为药物投递载体进行小分子化合物给药治疗肿瘤和反义核酸投递进行基因治疗；模拟细胞功能重建了ATP合成过程及模拟体内三酶偶联反应过程；作为近红外荧光探针在活体深层组织荧光成像技术等生物医学领域中的应用。
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| 关 键 词： | 聚合物囊泡 投递载体 纳米反应器 近红外荧光成像 |
Application of Polymersomes in Biomedical Domain |
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| WU Liyuan,MU Ying,SHI Wei. Application of Polymersomes in Biomedical Domain[J]. , 2011, 0(5): 443-446 |
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| Authors: | WU Liyuan MU Ying SHI Wei |
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| Affiliation: | 1 Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin Universi- ty, Changchun, 130021, China 2Research Center for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou, 310058, China |
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| Abstract: | Polymersomes newly emerging for the past few years are a kind of self-assembly soft nano materials. Due to their predominant physico-chemical property, they have caused tremendous attention and have been employed in some subjects. Here, we will introduce their application in biomedical domain： drugs delivery carriers to delivery free drugs for cancer therapy and antisense nucleotides for gene therapy, mimicry of cellular function for process of ATP synthesis and three-enzyme cascade reactions, near-infrared-emissive fluorescent probe for in vivo optical imaging of deep tissue. |
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| Keywords: | polymersomes delivery carriers nanoreactors near-infrared fluorescent imaging |
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