| 精子DNA甲基化异常与男性不育 |
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| 引用本文： | 纪梓良,段永刚,蔡志明.精子DNA甲基化异常与男性不育[J].国外医学：分子生物学分册,2011(5):455-460. |
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| 作者姓名： | 纪梓良 段永刚 蔡志明 |
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| 作者单位： | [1]北京大学深圳医院,深圳北京大学香港科技大学医学中心,广东省男性生殖与遗传重点实验室,广东省深圳市518036 [2]深圳市第二人民医院深圳大学第一附属医院,深圳大学泌尿生殖研究所,广东省深圳市515036 [3]汕头大学医学院,广东省汕头市515041 |
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| 基金项目： | 国家自然科学基金（No.81070529,30972992）,广东省医学科研基金（No.B2009614） |
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| 摘 要： | DNA甲基化／去甲基化是表观遗传学最重要的内容并可以控制基因的表达和印迹，越来越多的研究显示DNA甲基化异常与不育男性精子发生异常、特定肿瘤的发生、神经系统疾病、Rett综合征等有关。文章通过总结近来的相关研究资料来阐述精子发生过程中的DNA甲基化状态的改变，探讨精子DNA的甲基化异常与男性不育之间的联系，旨在为男性不育的治疗提供新的临床思路。
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| 关 键 词： | 精子DNA 甲基化 去甲基化 男性不育 |
Methylation Abnormality of Sperm DNA and Male Infertility |
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| Authors: | JI Ziliang DUAN Yonggang CAI Zhiming |
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| Institution: | 1 Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Guangdong Key Laboratory of Male Reproduction and Genetics, Shenzhen, Guangdong, 518036, China 2Shenzhen Second People＇s Hospital (The First Affiliated Hospital of Shenzhen University), Institute of Urology and Reproduction of Shenzhen University, Shenzhen, Guangdong, 518036, China 3 Shantou University Medical College, Shantou , Guangdong , 515041, China |
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| Abstract: | DNA methylation is thought to be a crucial content of epigenetics and regulates expression and imprinting of genome. Accumulating data demonstrate that abnormal DNA methylation is involved in spermatogenesis abnormality of male infertility, tumorigenesis, disease of nervous system and Rett syndrome, etc. This review aims to summarize the recent studies on the dynamic changes of sperm DNA methylation in spermatogenesis, discuss the relationship between sperm DNA methylation abnormality and male infertility, and provide a new perspective on treatment for male infertility. |
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| Keywords: | sperm DNA methylation demethylation male infertility |
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