酒石酸锑钾对人胃癌细胞HS-746T增殖和侵袭的影响

目的 研究酒石酸锑钾对人胃癌细胞HS-746T的作用.方法 采用MTT和Transwell方法分别观察VEGF和MMP-9蛋白分泌表达量.结果 酒石酸锑钾对HS-746T细胞的增殖和侵袭具有很强的抑制作用,抑制率随酒石酸锑钾浓度增大而增强,对HS-746T细胞增殖半数抑制浓度（IC50）为82.27 μmol/L;同时,酒石酸锑钾可明显降低人胃癌细胞HS-746T上清中VEGF和MMP-9的分泌表达.结论 酒石酸锑钾能抑制人胃癌细胞HS-746T的增殖和侵袭.

Effect of Ptassium Antimonyl Tartrate on Proliferation and Invasion of Human HS-746T Gastric Cancer Cell Line

AIM To investigate the effect of potassium antimonyl tartrate on proliferation and invasion of HS-746T human gastric cancer cells. Methods The proliferation and invasion of potassium antimonyl tartrate on HS-746T were examined by MTT and Transwell. The secretion of VEGF and MMP-9 was examined by ELISA. Results The inhibitory effect of potassium antimonyl tartrate on HS-746T cells was enhanced with the increase of its concentration （ICs0 = 82.27 μmol/L ）. Moreover, potassium antimonyl tartrate notably decreased the secretion of VEGF and MMP- 9. Conclusion These results indicated that potassium antimonyl tartrate might be of value in treatment of gastric cancer.