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Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc
Authors:Puca Rosa  Nardinocchi Lavinia  Bossi Gianluca  Sacchi Ada  Rechavi Gideon  Givol David  D'Orazi Gabriella
Affiliation:a Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, 00158 Rome, Italy
b Cancer Research Center, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
c Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel
d Department of Oncology and Neurosciences, University “G. d'Annunzio”, 66013 Chieti, Italy
Abstract:
Keywords:HIPK2   p53 conformation   Metallothioneins   MT2A   Zinc   Adriamycin   Conditional-RNA interference   Breast cancer   Combined chemotherapy
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