Differential utilization of calcitonin gene regulatory DNA sequences in cultured lines of medullary thyroid carcinoma and small-cell lung carcinoma. |
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| Authors: | A de Bustros R Y Lee D Compton T Y Tsong S B Baylin and B D Nelkin |
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| Institution: | School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231. |
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| Abstract: | Regulation of expression of the human calcitonin gene was found to differ between two tumor lines of different tissue origin, medullary thyroid carcinoma (TT line) and small-cell lung carcinoma (DMS53 line). Distal 5' DNA elements between -750 and -2000 exhibited a stronger basal activity in DMS53 than in TT cells, whereas proximal DNA sequences between -132 and -252 mediated a dramatic cyclic AMP response in TT but not DMS53 cells. |
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