Comparison of maritime pine oil and fish oil effects on plasma lipoproteins in apolipoprotein E-deficient mice |
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Authors: | Asset G Baugé E Wolff R L Fruchart J C Dallongeville J |
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Affiliation: | 1INSERM U-325, Lille, France. |
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Abstract: | The goal of this study was to compare the lipid lowering properties of maritime pine and fish oils in apolipoprotein E-deficient (KOE) mice, an animal model of hyperlipidemia. KOE mice were supplemented with either lard, fish or maritime pine oil (10% w/w) for one month. Compared to lard, fish and maritime pine oils decreased cholesterol (-31% and -52% respectively) and phospholipid (-41 and -52%) levels and increased triglyceride (+182% and +123%) levels. These lipid changes resulted in an enrichment in triglycerides and a depletion in cholesterol of VLDL+IDL plasma fraction as compared to lard-fed mice. These findings suggest that VLDL-triglyceride lipolysis is impaired in KOE mice fed fish or maritime pine oil. |
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