Emergence of resistance to glutaraldehyde in spores of Bacillus subtilis 168 |
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| Authors: | EGM Power BN Dancer AD Russell |
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| Institution: | Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff CF1 3XF, U.K.;Department of Applied Biology, University of Wales Institute of Science and Technology, Cardiff CF1 3XF, U.K. |
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| Abstract: | Abstract The emergence of resistance to glutaraldehyde in spores of Bacillus subtilis 168 was examined. Resistance to an organic solvent (toluene), heat and lysozyme were included for comparison. A sequential development of resistance was observed, with toluene resistance occuring early on in sporulation (stages III and IV), thermal resistance at early stage V, lysozyme resistance at middle stage V and glutaraldehyde resistance arising late in stage V. Studies with sporulation mutants also indicate that glutaraldehyde resistance is acquired even later than lysozyme resistance and may therefore possibly be considered as a very late marker event for sporulation, characterizing late stages of B. subtilis 168 spore formation. |
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| Keywords: | Bacillus subtilis Resistance Glutaraldehyde |
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